What is Apidra?

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Apidra (insulin glulisine) is an injection that contains insulin glulisine. Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin glulisine is a fast-acting insulin that starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. Apidra is used to improve blood sugar control in adults and children with diabetes mellitus. Apidra is used to treat type 1 or type 2 diabetes in adults, and type 1 diabetes children who are at least 4 years old.

Before taking this medicine

You should not use Apidra if you are allergic to insulin glulisine, or if you are having an episode of hypoglycemia (low blood sugar).

Apidra is not approved for use by anyone younger than 4 years old, and should not be used to treat type 2 diabetes in a child of any age.

To make sure Apidra is safe for you, tell your doctor if you have ever had:

• liver or kidney disease;
• low levels of potassium in your blood (hypokalemia); or
• diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you also take pioglitazone or rosiglitazone (sometimes contained in combinations with glimepiride or metformin). Taking certain oral diabetes medicines while you are using insulin may increase your risk of serious heart problems.

Tell your doctor if you are pregnant or breastfeeding.

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Follow your doctor’s instructions about using insulin if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

How should I use Apidra?

Use Apidra exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Apidra is injected under the skin, or given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine and injection pen or insulin pump. Ask your doctor or pharmacist if you don’t understand all instructions.

Prepare an injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Your healthcare provider will show you where on your body to inject Apidra. Use a different place each time you give an injection. Do not inject into the same place two times in a row.

After using Apidra, eat a meal within 15 minutes. If you did not use an injection before the meal, use the medicine within 20 minutes after you start eating.

If you use this medicine with an IV or insulin pump, do not mix or dilute Apidra with any other insulin.

If you use an injection pen, use only the pen that comes with Apidra. Attach a new needle before each use. Do not transfer the insulin from the pen into a syringe or infusion pump.

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